CN Patent

CN111560021B — 一种德高替尼中间体及其制备方法

Assigned to Shanghai Kunbo Jiurui Pharmaceutical Technology Development Co ltd · Expires 2023-05-26 · 3y expired

What this patent protects

本发明揭示了一种德高替尼(Delgocitinib)中间体(3S,4R)‑3‑甲基‑β‑氧代‑1,6‑双氮杂螺环[3,4]辛烷‑1‑丙腈及其制备方法，通过以常见化合物为起始原料，依次进行溴代、酰化、环合、取代以及缩合还原等反应，使其制备过程原料易得、经济环保。通过该中间体与4‑氯‑7H‑吡咯[2,3‑d]嘧啶之间的一步缩合并可制得德高替尼，从而为该原料药的制备提供了一条新的途径。

USPTO Abstract

本发明揭示了一种德高替尼(Delgocitinib)中间体(3S,4R)‑3‑甲基‑β‑氧代‑1,6‑双氮杂螺环[3,4]辛烷‑1‑丙腈及其制备方法，通过以常见化合物为起始原料，依次进行溴代、酰化、环合、取代以及缩合还原等反应，使其制备过程原料易得、经济环保。通过该中间体与4‑氯‑7H‑吡咯[2,3‑d]嘧啶之间的一步缩合并可制得德高替尼，从而为该原料药的制备提供了一条新的途径。

Drugs covered by this patent

Patent Metadata

Patent number
CN111560021B
Jurisdiction
CN
Classification
—
Expires
2023-05-26
Drug substance claim
No
Drug product claim
No
Assignee
Shanghai Kunbo Jiurui Pharmaceutical Technology Development Co ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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