CN Patent

CN111303093A — 一种溴甲纳曲酮杂质的制备方法

Assigned to Chongqing Medical and Pharmaceutical College · Expires 2020-06-19 · 6y expired

What this patent protects

本发明涉及一种溴甲纳曲酮杂质的制备方法，该杂质具有式(Ⅰ)的结构，方法由以下步骤组成：(1)将溴甲纳曲酮加入碱性溶液中，溴甲纳曲酮浓度为0.01～0.1g/ml；(2)调节温度至100～126℃；(3)制备色谱纯化浓缩即得。该方法操作简单，反应时间短，产物纯度在95％以上，可直接作为对照品对溴甲纳曲酮杂质进行定性定量研究，从而更有效地控制产品质量。

USPTO Abstract

本发明涉及一种溴甲纳曲酮杂质的制备方法，该杂质具有式(Ⅰ)的结构，方法由以下步骤组成：(1)将溴甲纳曲酮加入碱性溶液中，溴甲纳曲酮浓度为0.01～0.1g/ml；(2)调节温度至100～126℃；(3)制备色谱纯化浓缩即得。该方法操作简单，反应时间短，产物纯度在95％以上，可直接作为对照品对溴甲纳曲酮杂质进行定性定量研究，从而更有效地控制产品质量。

Drugs covered by this patent

methylnaltrexone-bromide (METHYLNALTREXONE BROMIDE)

Patent Metadata

Patent number: CN111303093A
Jurisdiction: CN
Classification: —
Expires: 2020-06-19
Drug substance claim: No
Drug product claim: No
Assignee: Chongqing Medical and Pharmaceutical College
Source: FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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