CN Patent

CN111171078A — 一种瑞德西韦的合成方法

Assigned to ALPHA PHARMACEUTICAL Co Ltd JIANGSU PROVINCE · Expires 2020-05-19 · 6y expired

What this patent protects

本发明涉及医药技术领域，尤其是一种瑞德西韦的合成方法，具体为：先合成(3aR,4R,6R,6aR)‑4‑(4‑氨基吡咯[2,1‑f][1,2,4]三嗪‑7‑基)‑6‑(羟基甲基)‑2‑苯基四氢呋喃并[3,4‑d][1,3]二氧杂环戊烯‑4‑腈；然后与(2S)‑2‑((4‑硝基苯氧基)(苯氧基)磷酰基氨基)丙酸‑2‑乙基丁酯反应，形成(2S)‑2‑(((3aR,4R,6R,6aR)‑6‑(4‑氨基吡咯[2,1‑f][1,2,4]三嗪‑7‑基)‑6‑氰基‑2‑苯基四氢呋喃并[3,4‑d][1,3]二氧杂环戊烯‑4‑基)甲氧基)(苯氧基)磷酰基氨基)丙酸‑2‑…

USPTO Abstract

本发明涉及医药技术领域，尤其是一种瑞德西韦的合成方法，具体为：先合成(3aR,4R,6R,6aR)‑4‑(4‑氨基吡咯[2,1‑f][1,2,4]三嗪‑7‑基)‑6‑(羟基甲基)‑2‑苯基四氢呋喃并[3,4‑d][1,3]二氧杂环戊烯‑4‑腈；然后与(2S)‑2‑((4‑硝基苯氧基)(苯氧基)磷酰基氨基)丙酸‑2‑乙基丁酯反应，形成(2S)‑2‑(((3aR,4R,6R,6aR)‑6‑(4‑氨基吡咯[2,1‑f][1,2,4]三嗪‑7‑基)‑6‑氰基‑2‑苯基四氢呋喃并[3,4‑d][1,3]二氧杂环戊烯‑4‑基)甲氧基)(苯氧基)磷酰基氨基)丙酸‑2‑乙基丁酯；然后经脱保护，形成(2S)‑2‑((((2R,3S,4R,5R)‑5‑(4‑氨基吡咯[2,1‑f][1,2,4]三嗪‑7‑基)‑5‑氰基‑3，4‑二羟基四氢呋喃‑2‑基)甲氧基)(苯氧基)磷酰基氨基)丙酸‑2‑乙基丁酯。

Drugs covered by this patent

Patent Metadata

Patent number
CN111171078A
Jurisdiction
CN
Classification
—
Expires
2020-05-19
Drug substance claim
No
Drug product claim
No
Assignee
ALPHA PHARMACEUTICAL Co Ltd JIANGSU PROVINCE
Source
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Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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