CN Patent

CN111171076A — 一种替诺福韦二聚体的制备方法

Assigned to Hefei Qiyang Biotechnology Co ltd · Expires 2020-05-19 · 6y expired

What this patent protects

本发明公开了一种替诺福韦二聚体的制备方法，包括如下步骤：取(R)‑9‑(2‑磷酸甲氧基丙基)‑腺嘌呤于非质子性溶剂中，在催化剂和缩合剂作用下反应，然后浓缩得到粗品；取粗品加水溶解，过滤，调节滤液pH＝2‑3，降温至10‑20℃，加反溶剂析晶，过滤，滤饼干燥得到替诺福韦二聚体。本发明制备工艺简捷、周期短，制得的替诺福韦二聚体的纯度高，标定含量高，可作为杂质标准品。

USPTO Abstract

本发明公开了一种替诺福韦二聚体的制备方法，包括如下步骤：取(R)‑9‑(2‑磷酸甲氧基丙基)‑腺嘌呤于非质子性溶剂中，在催化剂和缩合剂作用下反应，然后浓缩得到粗品；取粗品加水溶解，过滤，调节滤液pH＝2‑3，降温至10‑20℃，加反溶剂析晶，过滤，滤饼干燥得到替诺福韦二聚体。本发明制备工艺简捷、周期短，制得的替诺福韦二聚体的纯度高，标定含量高，可作为杂质标准品。

Drugs covered by this patent

Patent Metadata

Patent number
CN111171076A
Jurisdiction
CN
Classification
—
Expires
2020-05-19
Drug substance claim
No
Drug product claim
No
Assignee
Hefei Qiyang Biotechnology Co ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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