CN Patent

CN111072543B — 一种(3r,4s)-4-乙基吡咯烷-3-羧酸类化合物的制备方法及其应用

Assigned to Beijing Haimeitong Medical Technology Co ltd · Expires 2021-06-04 · 5y expired

What this patent protects

本发明实施例公开了一种(3R,4S)‑4‑乙基吡咯烷‑3‑羧酸类化合物的制备方法及其应用，涉及药物合成技术领域。本发明以甘氨酸乙酯为原料，依次经氨基加保护基、闭环、取代、偶联、催化加氢、水解和脱保护基合成得到(3R,4S)‑4‑乙基吡咯烷‑3‑羧酸。该反应合成的目标产物具有较高的产率和手性纯度，同时还具有原料简单易得，合成路线简单，反应条件温和，分离纯化操作简单，合成成本低的优点。

USPTO Abstract

本发明实施例公开了一种(3R,4S)‑4‑乙基吡咯烷‑3‑羧酸类化合物的制备方法及其应用，涉及药物合成技术领域。本发明以甘氨酸乙酯为原料，依次经氨基加保护基、闭环、取代、偶联、催化加氢、水解和脱保护基合成得到(3R,4S)‑4‑乙基吡咯烷‑3‑羧酸。该反应合成的目标产物具有较高的产率和手性纯度，同时还具有原料简单易得，合成路线简单，反应条件温和，分离纯化操作简单，合成成本低的优点。

Drugs covered by this patent

Patent Metadata

Patent number
CN111072543B
Jurisdiction
CN
Classification
—
Expires
2021-06-04
Drug substance claim
No
Drug product claim
No
Assignee
Beijing Haimeitong Medical Technology Co ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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