CN Patent

CN111057003A — 一种立他司特中间体5,7-二氯-1,2,3,4-四氢异喹啉的合成方法

Assigned to Guang'an Kingday Pharma & Chem Co ltd · Expires 2020-04-24 · 6y expired

What this patent protects

本发明公开了一种立他司特中间体5,7‑二氯‑1,2,3,4‑四氢异喹啉的合成方法，该方法包括：以2,4‑二氯苯甲醛为起始物料，通过硝醇缩合消去、还原、氨基保护、环合、脱保护等反应得到5,7‑二氯‑1,2,3,4‑四氢异喹啉。该合成方法不仅避免了使用昂贵原料，而且工艺路线简单、原料易得、条件温和、生产成本有效降低，适合放大生产。

USPTO Abstract

本发明公开了一种立他司特中间体5,7‑二氯‑1,2,3,4‑四氢异喹啉的合成方法，该方法包括：以2,4‑二氯苯甲醛为起始物料，通过硝醇缩合消去、还原、氨基保护、环合、脱保护等反应得到5,7‑二氯‑1,2,3,4‑四氢异喹啉。该合成方法不仅避免了使用昂贵原料，而且工艺路线简单、原料易得、条件温和、生产成本有效降低，适合放大生产。

Drugs covered by this patent

Patent Metadata

Patent number
CN111057003A
Jurisdiction
CN
Classification
—
Expires
2020-04-24
Drug substance claim
No
Drug product claim
No
Assignee
Guang'an Kingday Pharma & Chem Co ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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