CN Patent

CN110563710B — 一种马来酸阿法替尼的制备方法

Assigned to Guangdong Annol Pharmaceutical Co ltd · Expires 2020-05-19 · 6y expired

What this patent protects

本发明属于药物制备技术领域，具体涉及一种马来酸阿法替尼的制备方法。本发明的马来酸阿法替尼由N 4 ‑(3‑氯‑4‑氟苯基)‑7‑[[(3S)‑四氢‑3‑呋喃基]氧基]‑4,6‑喹唑啉二胺与二乙基磷乙酸反应得到中间体Ⅰ，再加入二甲氨基乙缩醛二乙醇发生Horner‑Wadsworth‑Emmons反应得到中间体Ⅱ，最后中间体Ⅱ与马来酸成盐得到马来酸阿法替尼。本发明制得的马来酸阿法替尼杂质含量低，基本不残留精制时采用的溶剂，且性质稳定。

USPTO Abstract

本发明属于药物制备技术领域，具体涉及一种马来酸阿法替尼的制备方法。本发明的马来酸阿法替尼由N 4 ‑(3‑氯‑4‑氟苯基)‑7‑[[(3S)‑四氢‑3‑呋喃基]氧基]‑4,6‑喹唑啉二胺与二乙基磷乙酸反应得到中间体Ⅰ，再加入二甲氨基乙缩醛二乙醇发生Horner‑Wadsworth‑Emmons反应得到中间体Ⅱ，最后中间体Ⅱ与马来酸成盐得到马来酸阿法替尼。本发明制得的马来酸阿法替尼杂质含量低，基本不残留精制时采用的溶剂，且性质稳定。

Drugs covered by this patent

Patent Metadata

Patent number
CN110563710B
Jurisdiction
CN
Classification
—
Expires
2020-05-19
Drug substance claim
No
Drug product claim
No
Assignee
Guangdong Annol Pharmaceutical Co ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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