CN Patent

CN110507640A — 4-苯基丁酸钠盐在制备治疗I型Bartter综合征药物中的应用

Assigned to Nanjing Children's Hospital of Nanjing Medical University · Expires 2019-11-29 · 6y expired

What this patent protects

本发明公开了4‑苯基丁酸钠盐在制备治疗I型Bartter综合征的药物中的应用。本发明能增加NKCC2突变体L463S、L479V的膜蛋白表达，改善突变体蛋白的构象稳定性，从而提高加工和运输成熟蛋白至细胞表面，最终提高转运体的功能，特别适用治疗由SLC12A1基因突变所致的I型Bartter综合征。

USPTO Abstract

本发明公开了4‑苯基丁酸钠盐在制备治疗I型Bartter综合征的药物中的应用。本发明能增加NKCC2突变体L463S、L479V的膜蛋白表达，改善突变体蛋白的构象稳定性，从而提高加工和运输成熟蛋白至细胞表面，最终提高转运体的功能，特别适用治疗由SLC12A1基因突变所致的I型Bartter综合征。

Drugs covered by this patent

Patent Metadata

Patent number: CN110507640A
Jurisdiction: CN
Classification: —
Expires: 2019-11-29
Drug substance claim: No
Drug product claim: No
Assignee: Nanjing Children's Hospital of Nanjing Medical University
Source: FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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