CN Patent

CN110372609B — 一种噁拉戈利钠盐的纯化方法

Assigned to Aurisco Pharmaceutical Co ltd · Expires 2021-04-09 · 5y expired

What this patent protects

本发明涉及制药领域，具体涉及一种噁拉戈利钠盐的纯化方法，其包括以下步骤：将噁拉戈利钠盐粗品溶于水中，调节pH至酸性析出固体，过滤后滤饼溶于醚类溶剂，水洗后浓干，加入有机溶剂和碱性物质，室温下反应水解成盐，浓缩后加入水和酯类溶剂，分层后调节pH至碱性，随后用酮类溶剂萃取，干燥，浓缩，加入烷烃类溶剂打浆，过滤，减压干燥得到高纯度噁拉戈利钠盐。本发明所述的纯化方法操作简便，生产成本低，产品纯度和收率高，适合工业化生产。

USPTO Abstract

本发明涉及制药领域，具体涉及一种噁拉戈利钠盐的纯化方法，其包括以下步骤：将噁拉戈利钠盐粗品溶于水中，调节pH至酸性析出固体，过滤后滤饼溶于醚类溶剂，水洗后浓干，加入有机溶剂和碱性物质，室温下反应水解成盐，浓缩后加入水和酯类溶剂，分层后调节pH至碱性，随后用酮类溶剂萃取，干燥，浓缩，加入烷烃类溶剂打浆，过滤，减压干燥得到高纯度噁拉戈利钠盐。本发明所述的纯化方法操作简便，生产成本低，产品纯度和收率高，适合工业化生产。

Drugs covered by this patent

Patent Metadata

Patent number: CN110372609B
Jurisdiction: CN
Classification: —
Expires: 2021-04-09
Drug substance claim: No
Drug product claim: No
Assignee: Aurisco Pharmaceutical Co ltd
Source: FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

Track this patent

Get a daily-checked alert when vulnerability score, expiry, classification, or assignee changes. Email, Slack, or Teams delivery. Pro: 50 watches, Free: 3.