CN Patent

CN110272409A — 一步法合成沃诺拉赞的新方法

Assigned to Nanjing Biodealpharm Co Ltd · Expires 2019-09-24 · 7y expired

What this patent protects

本发明公开了一步法合成沃诺拉赞的新方法，属于医药领域。该方法将化合物5‑(2‑氟苯基)‑1H‑吡咯‑3‑甲醛溶解于有机溶剂，加入氢氧化钾、四丁基溴化铵和3‑吡啶磺酰氯，搅拌反应1～2小时后直接加入甲胺醇溶液和金属硼氢化物制备沃诺拉赞。该工艺步骤短，成本低，收率高，环保、安全，适用工业化大规模生产。

USPTO Abstract

本发明公开了一步法合成沃诺拉赞的新方法，属于医药领域。该方法将化合物5‑(2‑氟苯基)‑1H‑吡咯‑3‑甲醛溶解于有机溶剂，加入氢氧化钾、四丁基溴化铵和3‑吡啶磺酰氯，搅拌反应1～2小时后直接加入甲胺醇溶液和金属硼氢化物制备沃诺拉赞。该工艺步骤短，成本低，收率高，环保、安全，适用工业化大规模生产。

Drugs covered by this patent

Patent Metadata

Patent number
CN110272409A
Jurisdiction
CN
Classification
—
Expires
2019-09-24
Drug substance claim
No
Drug product claim
No
Assignee
Nanjing Biodealpharm Co Ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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