CN Patent

CN110183455B — 氮杂双环[3.2.1]辛-3-酮类化合物及其制备方法与其用途

Assigned to China Medical University Taiwan · Expires 2021-04-20 · 5y expired

What this patent protects

本发明公开了一种氮杂双环[3.2.1]辛‑3‑酮类化合物、含有该化合物的组合物及其制备方法，属于医药领域。本发明通过以左旋樟脑为起始原料与羟胺反应制得左旋樟脑肟，经贝克曼重、与溴丙炔反应，最终与叠氮取代苯经Huisgen环加成反应得到氮杂双环[3.2.1]辛‑3‑酮类化合物。本发明制备出的氮杂双环[3.2.1]辛‑3‑酮类化合物结构新颖，在体外抗肿瘤活性试验中具有显著效果。

USPTO Abstract

本发明公开了一种氮杂双环[3.2.1]辛‑3‑酮类化合物、含有该化合物的组合物及其制备方法，属于医药领域。本发明通过以左旋樟脑为起始原料与羟胺反应制得左旋樟脑肟，经贝克曼重、与溴丙炔反应，最终与叠氮取代苯经Huisgen环加成反应得到氮杂双环[3.2.1]辛‑3‑酮类化合物。本发明制备出的氮杂双环[3.2.1]辛‑3‑酮类化合物结构新颖，在体外抗肿瘤活性试验中具有显著效果。

Drugs covered by this patent

Patent Metadata

Patent number
CN110183455B
Jurisdiction
CN
Classification
—
Expires
2021-04-20
Drug substance claim
No
Drug product claim
No
Assignee
China Medical University Taiwan
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

Track this patent

Get a daily-checked alert when vulnerability score, expiry, classification, or assignee changes. Email, Slack, or Teams delivery. Pro: 50 watches, Free: 3.