CN Patent

CN110105372B — 一种r-7-(苄氧基)-四氢-1h-恶嗪并吡啶并-三嗪-6,8-二酮的制备方法

Assigned to Nanjing Huanran Bio Tech Co ltd · Expires 2022-05-10 · 4y expired

What this patent protects

本发明涉及一种R‑7‑(苄氧基)‑四氢‑1H‑恶嗪并吡啶并‑三嗪‑6,8‑二酮的制备方法的合成路线，以烯丙基3‑氧代吗啉‑4‑羧酸酯为原料，经缩合反应、硼氢化还原反应、环合反应、酰胺化反应、脱保护反应五步反应高产率合成R‑7‑(苄氧基)‑四氢‑1H‑恶嗪并吡啶并‑三嗪‑6,8‑二酮。本发明提供的巴洛沙韦中间体制备方法是一种高收率、低成本、易操作、适宜工业化的制备方法。

USPTO Abstract

本发明涉及一种R‑7‑(苄氧基)‑四氢‑1H‑恶嗪并吡啶并‑三嗪‑6,8‑二酮的制备方法的合成路线，以烯丙基3‑氧代吗啉‑4‑羧酸酯为原料，经缩合反应、硼氢化还原反应、环合反应、酰胺化反应、脱保护反应五步反应高产率合成R‑7‑(苄氧基)‑四氢‑1H‑恶嗪并吡啶并‑三嗪‑6,8‑二酮。本发明提供的巴洛沙韦中间体制备方法是一种高收率、低成本、易操作、适宜工业化的制备方法。

Drugs covered by this patent

Patent Metadata

Patent number
CN110105372B
Jurisdiction
CN
Classification
—
Expires
2022-05-10
Drug substance claim
No
Drug product claim
No
Assignee
Nanjing Huanran Bio Tech Co ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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