CN109796401B — 一种瑞戈非尼原料药的制备方法
Assigned to Xinxiang Shuanglu Pharmaceutical Co ltd · Expires 2023-10-17 · 3y expired
What this patent protects
本发明公开了一种瑞戈非尼原料药的制备方法，该方法以4‑氯‑N‑甲基吡啶‑2‑甲酰胺、2‑氟‑4‑羟基苯胺（4‑氨基‑3‑氟苯酚）、4‑氯‑3‑（三氟甲基）苯异氰酸酯为原料，经4‑（4‑氨基‑3‑三氟苯氧基）‑N‑甲基吡啶‑2‑甲酰胺、4‑[4‑({[4‑氯‑3‑（三氟甲基）苯基]氨基甲酰}氨基）‑3‑氟苯基氨基]‑N‑甲基吡啶‑2‑甲酰胺，上结晶水得瑞戈菲尼（4‑[4‑({[4‑氯‑3‑（三氟甲基）苯基]氨基甲酰}氨基）‑3‑氟苯基氨基]‑N‑甲基吡啶‑2‑甲酰胺一水合物，精制得到瑞戈菲尼原料药，整个生产过程两步反应，四个操作过程，步骤短，收率高，纯度高…
USPTO Abstract
本发明公开了一种瑞戈非尼原料药的制备方法，该方法以4‑氯‑N‑甲基吡啶‑2‑甲酰胺、2‑氟‑4‑羟基苯胺（4‑氨基‑3‑氟苯酚）、4‑氯‑3‑（三氟甲基）苯异氰酸酯为原料，经4‑（4‑氨基‑3‑三氟苯氧基）‑N‑甲基吡啶‑2‑甲酰胺、4‑[4‑({[4‑氯‑3‑（三氟甲基）苯基]氨基甲酰}氨基）‑3‑氟苯基氨基]‑N‑甲基吡啶‑2‑甲酰胺，上结晶水得瑞戈菲尼（4‑[4‑({[4‑氯‑3‑（三氟甲基）苯基]氨基甲酰}氨基）‑3‑氟苯基氨基]‑N‑甲基吡啶‑2‑甲酰胺一水合物，精制得到瑞戈菲尼原料药，整个生产过程两步反应，四个操作过程，步骤短，收率高，纯度高，杂质少，摩尔收率大于45%，重量收率接近100%。
Drugs covered by this patent
Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.
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