CN Patent

CN109701030A — 聚乙二醇化小分子药物的制备方法

Assigned to Hunan Huateng Pharmaceutical Co Ltd · Expires 2019-05-03 · 7y expired

What this patent protects

本发明公开了一种聚乙二醇化小分子药物的制备方法，具体涉及到洛伐他汀的聚乙二醇修饰物的制备方法。第一步将聚乙二醇进行氧化反应得到聚乙二醇单羧酸；第二步把聚乙二醇单羧酸与洛伐他汀进行缩合反应得到目标产物，即聚乙二醇修饰的洛伐他汀化合物。洛伐他汀的聚乙二醇修饰物中含有可降解的酯键，可达到缓释效果；具有两亲性，提高洛伐他汀的水溶性，利于人体吸收，减轻洛伐他汀的刺激作用。

USPTO Abstract

本发明公开了一种聚乙二醇化小分子药物的制备方法，具体涉及到洛伐他汀的聚乙二醇修饰物的制备方法。第一步将聚乙二醇进行氧化反应得到聚乙二醇单羧酸；第二步把聚乙二醇单羧酸与洛伐他汀进行缩合反应得到目标产物，即聚乙二醇修饰的洛伐他汀化合物。洛伐他汀的聚乙二醇修饰物中含有可降解的酯键，可达到缓释效果；具有两亲性，提高洛伐他汀的水溶性，利于人体吸收，减轻洛伐他汀的刺激作用。

Drugs covered by this patent

Patent Metadata

Patent number: CN109701030A
Jurisdiction: CN
Classification: —
Expires: 2019-05-03
Drug substance claim: No
Drug product claim: No
Assignee: Hunan Huateng Pharmaceutical Co Ltd
Source: FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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