CN Patent

CN109651265A — 一种Elagolix的制备方法

Assigned to Pharmaceutical Co Ltd Anhui Connaught Whole · Expires 2019-04-19 · 7y expired

What this patent protects

本发明公开了一种Elagolix的制备方法，其特征在于，如式II所示的(R)‑3‑(2‑氨基‑2‑苯乙基)‑5‑(2‑氟‑3‑甲氧基苯基)‑1‑(2‑氟‑6‑(三氟甲基)苄基)‑6‑甲基嘧啶‑2,4(1H，3H)‑二酮与如式V所示的4‑氧代丁酸经还原胺化反应得到如式I所示的的Elagolix；本发明的优点在于，经过一步反应就可获得目标产物，大大缩短了合成路线，简化制备过程；该路线的副反应少，减少了杂质的引入，使得后续纯化处理简单方便，有效提高了目标产物的纯度。

USPTO Abstract

本发明公开了一种Elagolix的制备方法，其特征在于，如式II所示的(R)‑3‑(2‑氨基‑2‑苯乙基)‑5‑(2‑氟‑3‑甲氧基苯基)‑1‑(2‑氟‑6‑(三氟甲基)苄基)‑6‑甲基嘧啶‑2,4(1H，3H)‑二酮与如式V所示的4‑氧代丁酸经还原胺化反应得到如式I所示的的Elagolix；本发明的优点在于，经过一步反应就可获得目标产物，大大缩短了合成路线，简化制备过程；该路线的副反应少，减少了杂质的引入，使得后续纯化处理简单方便，有效提高了目标产物的纯度。

Drugs covered by this patent

Patent Metadata

Patent number: CN109651265A
Jurisdiction: CN
Classification: —
Expires: 2019-04-19
Drug substance claim: No
Drug product claim: No
Assignee: Pharmaceutical Co Ltd Anhui Connaught Whole
Source: FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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