CN Patent

CN109498815B — 重组人激肽释放酶的化学修饰物及其应用

Assigned to ZONHON BIOPHARMA INSTITUTE Inc · Expires 2022-07-22 · 4y expired

What this patent protects

本发明涉及重组人组织激肽释放酶的化学修饰物及其应用。所述重组人组织激肽释放酶的编码基因如SEQ ID No：4所示，所述化学修饰为聚乙二醇修饰。本发明提供的重组人组织激肽释放酶的化学修饰物在具有半衰期明显延长、免疫原性显著降低、结构稳定均一等优点的基础上，更大程度地提高了其生物学活性，尤其在治疗脑卒中方面更加显著。

USPTO Abstract

本发明涉及重组人组织激肽释放酶的化学修饰物及其应用。所述重组人组织激肽释放酶的编码基因如SEQ ID No：4所示，所述化学修饰为聚乙二醇修饰。本发明提供的重组人组织激肽释放酶的化学修饰物在具有半衰期明显延长、免疫原性显著降低、结构稳定均一等优点的基础上，更大程度地提高了其生物学活性，尤其在治疗脑卒中方面更加显著。

Drugs covered by this patent

Patent Metadata

Patent number
CN109498815B
Jurisdiction
CN
Classification
—
Expires
2022-07-22
Drug substance claim
No
Drug product claim
No
Assignee
ZONHON BIOPHARMA INSTITUTE Inc
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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