CN Patent

CN109053683A — 来那替尼马来酸盐晶型c的制备方法以及来那替尼马来酸盐晶型c

Assigned to Suzhou Crystal Cloud Medicine Polytron Technologies Inc · Expires 2018-12-21 · 7y expired

What this patent protects

本发明涉及一种来那替尼马来酸盐晶型C的制备方法以及来那替尼马来酸盐晶型C。包括形成溶解于二元溶剂中的来那替尼马来酸盐溶液的步骤，所述二元溶剂由水和与水互溶的有机溶剂组成；包括将所述来那替尼马来酸盐溶液与作为晶种的来那替尼马来酸盐晶型C以及反溶剂混合的步骤；包括经熟化得到沉淀的步骤。该方法收率高，工艺过程稳定易控。该方法获得的那替尼马来酸盐晶型C，纯度高，结晶度高，结晶形态好，不易黏结，流动性好，利于后续制剂加工。

USPTO Abstract

本发明涉及一种来那替尼马来酸盐晶型C的制备方法以及来那替尼马来酸盐晶型C。包括形成溶解于二元溶剂中的来那替尼马来酸盐溶液的步骤，所述二元溶剂由水和与水互溶的有机溶剂组成；包括将所述来那替尼马来酸盐溶液与作为晶种的来那替尼马来酸盐晶型C以及反溶剂混合的步骤；包括经熟化得到沉淀的步骤。该方法收率高，工艺过程稳定易控。该方法获得的那替尼马来酸盐晶型C，纯度高，结晶度高，结晶形态好，不易黏结，流动性好，利于后续制剂加工。

Drugs covered by this patent

Patent Metadata

Patent number
CN109053683A
Jurisdiction
CN
Classification
—
Expires
2018-12-21
Drug substance claim
No
Drug product claim
No
Assignee
Suzhou Crystal Cloud Medicine Polytron Technologies Inc
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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