CN Patent

CN108976114A — 一种格隆溴铵中间体2-环戊基-2-羟基苯乙酸的纯化方法

Assigned to Zhejiang Huahai Pharmaceutical Co Ltd · Expires 2018-12-11 · 7y expired

What this patent protects

本发明公开了格隆溴铵中间体2‑环戊基‑2‑羟基苯乙酸的纯化方法，包括：(1)将2‑环戊基‑2‑羟基苯乙酸粗品在乙醇和水的混合溶剂中加热溶解后，冷却析晶，过滤得固体；(2)将步骤(1)得到的固体在甲苯中加热溶解后，冷却析晶，过滤得2‑环戊基‑2‑羟基苯乙酸固体。该方法能够有效地除去各种杂质，显著提高了产品的纯度，HPLC纯度大于98.0％，并最大限度的降低了2‑环戊基‑2‑羟基苯乙酸的损失，提高了收率，适合工业化生产。

USPTO Abstract

本发明公开了格隆溴铵中间体2‑环戊基‑2‑羟基苯乙酸的纯化方法，包括：(1)将2‑环戊基‑2‑羟基苯乙酸粗品在乙醇和水的混合溶剂中加热溶解后，冷却析晶，过滤得固体；(2)将步骤(1)得到的固体在甲苯中加热溶解后，冷却析晶，过滤得2‑环戊基‑2‑羟基苯乙酸固体。该方法能够有效地除去各种杂质，显著提高了产品的纯度，HPLC纯度大于98.0％，并最大限度的降低了2‑环戊基‑2‑羟基苯乙酸的损失，提高了收率，适合工业化生产。

Drugs covered by this patent

Patent Metadata

Patent number
CN108976114A
Jurisdiction
CN
Classification
—
Expires
2018-12-11
Drug substance claim
No
Drug product claim
No
Assignee
Zhejiang Huahai Pharmaceutical Co Ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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