CN Patent

CN108586325A — 一种Betrixaban中间体的制备方法

Assigned to Shanghai Medical Technology Co Ltd · Expires 2018-09-28 · 8y expired

What this patent protects

本发明公开了一种制备Betrixaban的关键中间体化合物B的方法，采用水合肼作还原剂，氯化铁催化条件下，将下式化合物A还原得到。与已有的制备方法相比，本发明制备方法反应可控，反应条件温和、后处理简单、收率高，无脱氯杂质生成，收率(yield)>90％，纯度(purity)>98％，因此生产成本也大幅下降，更适于工业化生产。

USPTO Abstract

本发明公开了一种制备Betrixaban的关键中间体化合物B的方法，采用水合肼作还原剂，氯化铁催化条件下，将下式化合物A还原得到。与已有的制备方法相比，本发明制备方法反应可控，反应条件温和、后处理简单、收率高，无脱氯杂质生成，收率(yield)>90％，纯度(purity)>98％，因此生产成本也大幅下降，更适于工业化生产。

Drugs covered by this patent

Patent Metadata

Patent number
CN108586325A
Jurisdiction
CN
Classification
—
Expires
2018-09-28
Drug substance claim
No
Drug product claim
No
Assignee
Shanghai Medical Technology Co Ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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