CN Patent

CN108440596B — 一种半富马酸替诺福韦艾拉酚胺的新型制备工艺

Assigned to Kexing Biopharmaceutical Co ltd · Expires 2020-07-03 · 6y expired

What this patent protects

本发明公开了一种半富马酸替诺福韦艾拉酚胺的新型制备工艺，具体地，本发明提供了一种半富马酸替诺福韦艾拉酚胺的制备方法，该方法将替诺福韦艾拉酚胺粗品加入异丁醇中，加热溶解后加入乙腈和正已烷的混合溶液进行精制；然后将获得的替诺福韦艾拉酚胺精制品和富马酸加入乙腈中，成盐结晶获得半富马酸替诺福韦艾拉酚胺。本发明的方法可以有效去除替诺福韦艾拉酚胺粗品中的非对映异构体杂质，获得高品质的半富马酸替诺福韦艾拉酚胺。

USPTO Abstract

本发明公开了一种半富马酸替诺福韦艾拉酚胺的新型制备工艺，具体地，本发明提供了一种半富马酸替诺福韦艾拉酚胺的制备方法，该方法将替诺福韦艾拉酚胺粗品加入异丁醇中，加热溶解后加入乙腈和正已烷的混合溶液进行精制；然后将获得的替诺福韦艾拉酚胺精制品和富马酸加入乙腈中，成盐结晶获得半富马酸替诺福韦艾拉酚胺。本发明的方法可以有效去除替诺福韦艾拉酚胺粗品中的非对映异构体杂质，获得高品质的半富马酸替诺福韦艾拉酚胺。

Drugs covered by this patent

Patent Metadata

Patent number
CN108440596B
Jurisdiction
CN
Classification
—
Expires
2020-07-03
Drug substance claim
No
Drug product claim
No
Assignee
Kexing Biopharmaceutical Co ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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