CN Patent

CN108289881A — 用于治疗纤维化的赛尼克韦罗联合疗法

Assigned to Tobira Therapeutics Inc · Expires 2018-07-17 · 8y expired

What this patent protects

赛尼克韦罗(CVC)是与C‑C趋化因子受体5型(CCR5)和C‑C趋化因子受体2型(CCR2)结合的配体的口服活性拮抗剂。CVC阻断RANTES、MIP‑1α和MIP‑1β与CCR5的结合，以及MCP‑1/CCL2与CCR2的结合。本文提供了治疗纤维化和相关病状的方法，其包括共施用CVC与趋化因子拮抗剂、FXR激动剂、高剂量维生素E(>400iU/d)、过氧化物酶体增殖物激活受体α(PPAR‑α)激动剂、PPAR‑γ激动剂和/或PPAR‑δ激动剂。

USPTO Abstract

赛尼克韦罗(CVC)是与C‑C趋化因子受体5型(CCR5)和C‑C趋化因子受体2型(CCR2)结合的配体的口服活性拮抗剂。CVC阻断RANTES、MIP‑1α和MIP‑1β与CCR5的结合，以及MCP‑1/CCL2与CCR2的结合。本文提供了治疗纤维化和相关病状的方法，其包括共施用CVC与趋化因子拮抗剂、FXR激动剂、高剂量维生素E(>400iU/d)、过氧化物酶体增殖物激活受体α(PPAR‑α)激动剂、PPAR‑γ激动剂和/或PPAR‑δ激动剂。

Drugs covered by this patent

Patent Metadata

Patent number
CN108289881A
Jurisdiction
CN
Classification
—
Expires
2018-07-17
Drug substance claim
No
Drug product claim
No
Assignee
Tobira Therapeutics Inc
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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