CN Patent

CN108191747A — 一种Abemaciclib中间体的制备方法

Assigned to INSTITUTE OF DAFENG MARINE INDUSTRY NANJING UNIVERSITY OF TECHNOLOGY · Expires 2018-06-22 · 8y expired

What this patent protects

本发明公开了一种Abemaciclib中间体的制备方法，属于医药化工领域。本发明的制备方法，通过先后还原5‑(4‑乙基哌嗪‑1‑羰基)‑2‑硝基吡啶的羰基和硝基，从而得到Abemaciclib中间体5‑(4‑乙基‑脈嗓‑1‑基甲基)‑吡啶‑2‑基胺，该方法所用原料和试剂容易获得,反应条件温和，避免使用有毒、有刺激性和强腐蚀性试剂，绿色环保，制备简单易操作，所得产品具有高收率和高纯度，特别适合工业化生产。

USPTO Abstract

本发明公开了一种Abemaciclib中间体的制备方法，属于医药化工领域。本发明的制备方法，通过先后还原5‑(4‑乙基哌嗪‑1‑羰基)‑2‑硝基吡啶的羰基和硝基，从而得到Abemaciclib中间体5‑(4‑乙基‑脈嗓‑1‑基甲基)‑吡啶‑2‑基胺，该方法所用原料和试剂容易获得,反应条件温和，避免使用有毒、有刺激性和强腐蚀性试剂，绿色环保，制备简单易操作，所得产品具有高收率和高纯度，特别适合工业化生产。

Drugs covered by this patent

Patent Metadata

Patent number
CN108191747A
Jurisdiction
CN
Classification
—
Expires
2018-06-22
Drug substance claim
No
Drug product claim
No
Assignee
INSTITUTE OF DAFENG MARINE INDUSTRY NANJING UNIVERSITY OF TECHNOLOGY
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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