CN Patent

CN108164459B — 甲苯磺酸索拉非尼晶型iii的制备方法

Assigned to Shanghai Acebright Pharmaceutical Co ltd · Expires 2021-07-27 · 5y expired

What this patent protects

本发明提供了一种甲苯磺酸索拉非尼晶型III的制备方法，将对苯甲磺酸和索拉非尼游离碱的有机溶剂加入到甲醇中析晶，或者将索拉非尼游离碱的有机溶剂加入到对苯甲磺酸的甲醇溶液中析晶得到甲苯磺酸索拉非尼的甲醇溶剂化物，最后通过脱溶剂得到晶型III。该方法得到的甲醇化物粒度小，较易烘成晶型III，最后晶型III具有流动性好、纯度高、质量合格与晶型I溶出相似等特性，且该方法操作简单，收率高，适合工业化生产。

USPTO Abstract

本发明提供了一种甲苯磺酸索拉非尼晶型III的制备方法，将对苯甲磺酸和索拉非尼游离碱的有机溶剂加入到甲醇中析晶，或者将索拉非尼游离碱的有机溶剂加入到对苯甲磺酸的甲醇溶液中析晶得到甲苯磺酸索拉非尼的甲醇溶剂化物，最后通过脱溶剂得到晶型III。该方法得到的甲醇化物粒度小，较易烘成晶型III，最后晶型III具有流动性好、纯度高、质量合格与晶型I溶出相似等特性，且该方法操作简单，收率高，适合工业化生产。

Drugs covered by this patent

Patent Metadata

Patent number
CN108164459B
Jurisdiction
CN
Classification
—
Expires
2021-07-27
Drug substance claim
No
Drug product claim
No
Assignee
Shanghai Acebright Pharmaceutical Co ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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