CN Patent

CN108101852A — 一种奥拉帕尼的制备方法

Assigned to Shandong Yu Xin Pharmaceutcal Corp Ltd · Expires 2018-06-01 · 8y expired

What this patent protects

本发明公开了一种奥拉帕尼的制备方法。本发明采用化合物Ⅱ在AlMe 3 条件下进行酰胺化反应制得化合物Ⅲ，化合物Ⅲ水解后与1‑环丙甲酰基哌嗪反应，精制得终产品奥拉帕尼(Ⅰ)精品。该制备方法路线简单，容易操作，产品总收率高，副产物少，适合工业化生产。

USPTO Abstract

本发明公开了一种奥拉帕尼的制备方法。本发明采用化合物Ⅱ在AlMe 3 条件下进行酰胺化反应制得化合物Ⅲ，化合物Ⅲ水解后与1‑环丙甲酰基哌嗪反应，精制得终产品奥拉帕尼(Ⅰ)精品。该制备方法路线简单，容易操作，产品总收率高，副产物少，适合工业化生产。

Drugs covered by this patent

Patent Metadata

Patent number
CN108101852A
Jurisdiction
CN
Classification
—
Expires
2018-06-01
Drug substance claim
No
Drug product claim
No
Assignee
Shandong Yu Xin Pharmaceutcal Corp Ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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