CN Patent

CN107488171B — 一种阿法替尼制备方法

Assigned to Shandong New Time Pharmaceutical Co Ltd · Expires 2020-08-28 · 6y expired

What this patent protects

本发明揭示了一种新颖阿法替尼制备方法，包括如下步骤：N‑(3‑氯‑4‑氟苯基)‑7‑氟‑6‑硝基‑4‑喹唑啉胺还原得N‑(3‑氯‑4‑氟苯基)‑7‑氟‑6‑氨基‑4‑喹唑啉胺Ⅳ，再与二乙磷乙酸发生缩合反应得Ⅲ，再与二甲氨基乙醛缩二乙醇发生Wittig‑Horner‑Emmons反应得关键中间体Ⅱ,将化合物Ⅱ与(S)‑3‑羟基四氢呋喃进行取代反应得化合物Ⅰ。本发明方法收率高、纯度高。

USPTO Abstract

本发明揭示了一种新颖阿法替尼制备方法，包括如下步骤：N‑(3‑氯‑4‑氟苯基)‑7‑氟‑6‑硝基‑4‑喹唑啉胺还原得N‑(3‑氯‑4‑氟苯基)‑7‑氟‑6‑氨基‑4‑喹唑啉胺Ⅳ，再与二乙磷乙酸发生缩合反应得Ⅲ，再与二甲氨基乙醛缩二乙醇发生Wittig‑Horner‑Emmons反应得关键中间体Ⅱ,将化合物Ⅱ与(S)‑3‑羟基四氢呋喃进行取代反应得化合物Ⅰ。本发明方法收率高、纯度高。

Drugs covered by this patent

Patent Metadata

Patent number
CN107488171B
Jurisdiction
CN
Classification
—
Expires
2020-08-28
Drug substance claim
No
Drug product claim
No
Assignee
Shandong New Time Pharmaceutical Co Ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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