CN Patent

CN107281104B — 一种丁酸氯维地平磷脂复合物脂质体及其制备方法

Assigned to JINAN KANGHE MEDICAL TECHNOLOGY CO LTD · Expires 2021-02-02 · 5y expired

What this patent protects

本发明涉及药物制剂领域，具体涉及一种丁酸氯维地平磷脂复合物脂质体及其制备方法；本发明将一定比例的丁酸氯维地平与磷脂溶于有机溶剂中并在恒温水浴中搅拌，随后将混合液进行减压旋蒸、真空干燥，得到丁酸氯维地平磷脂复合物；再将适量的丁酸氯维地平磷脂复合物、磷脂、维生素E、胆固醇和去氧胆酸钠制成丁酸氯维地平磷脂复合物脂质体；本发明制备的丁酸氯维地平磷脂复合物脂质体的粒径在210nm左右，包封率高达98％左右，且稳定性好；该脂质体与普通的丁酸氯维地平脂质体相比，显著提高了药物的包封率，降低药物泄露的风险，制剂稳定性好，且制备方法操作简单，设备要求低，适合工业化生产。

USPTO Abstract

本发明涉及药物制剂领域，具体涉及一种丁酸氯维地平磷脂复合物脂质体及其制备方法；本发明将一定比例的丁酸氯维地平与磷脂溶于有机溶剂中并在恒温水浴中搅拌，随后将混合液进行减压旋蒸、真空干燥，得到丁酸氯维地平磷脂复合物；再将适量的丁酸氯维地平磷脂复合物、磷脂、维生素E、胆固醇和去氧胆酸钠制成丁酸氯维地平磷脂复合物脂质体；本发明制备的丁酸氯维地平磷脂复合物脂质体的粒径在210nm左右，包封率高达98％左右，且稳定性好；该脂质体与普通的丁酸氯维地平脂质体相比，显著提高了药物的包封率，降低药物泄露的风险，制剂稳定性好，且制备方法操作简单，设备要求低，适合工业化生产。

Drugs covered by this patent

Patent Metadata

Patent number
CN107281104B
Jurisdiction
CN
Classification
—
Expires
2021-02-02
Drug substance claim
No
Drug product claim
No
Assignee
JINAN KANGHE MEDICAL TECHNOLOGY CO LTD
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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