CN Patent

CN107176930B — 2-[5-溴-4-(4-氟代环丙基萘-1-基)-4h-1，2，4-三唑-3-基硫基]乙酸化合物及其应用

Assigned to Guangdong Scientific Finder Pharmaceutical Technology Co ltd · Expires 2020-12-01 · 5y expired

What this patent protects

本发明公开了一种具有式(I)结构的2‑[5‑溴‑4‑(4‑氟代环丙基萘‑1‑基)‑4H‑1，2，4‑三唑‑3‑基硫基]乙酸化合物及其药学上可接受的盐、光学异构体或前药；其中，R 1 、R 2 、R 3 、R 4 分别独自代表H或F，且R 1 、R 2 、R 3 、R 4 不全为H。本发明在Lesinurad Sodium的环丙基上引入F原子，其对尿酸转运蛋白1的抑制活性大大增强，并没有表现出严重副作用，特别适合用于制备预防或治疗高尿酸血症的药物。

USPTO Abstract

本发明公开了一种具有式(I)结构的2‑[5‑溴‑4‑(4‑氟代环丙基萘‑1‑基)‑4H‑1，2，4‑三唑‑3‑基硫基]乙酸化合物及其药学上可接受的盐、光学异构体或前药；其中，R 1 、R 2 、R 3 、R 4 分别独自代表H或F，且R 1 、R 2 、R 3 、R 4 不全为H。本发明在Lesinurad Sodium的环丙基上引入F原子，其对尿酸转运蛋白1的抑制活性大大增强，并没有表现出严重副作用，特别适合用于制备预防或治疗高尿酸血症的药物。

Drugs covered by this patent

Patent Metadata

Patent number
CN107176930B
Jurisdiction
CN
Classification
—
Expires
2020-12-01
Drug substance claim
No
Drug product claim
No
Assignee
Guangdong Scientific Finder Pharmaceutical Technology Co ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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