CN Patent

CN107033120B — 2-(2,2-二氟苯并[d][1,3]二氧杂环戊烯-5-基)乙氰的制备方法

Assigned to Henan Yuchen Pharmaceutical Co ltd · Expires 2020-03-17 · 6y expired

What this patent protects

本发明涉及一种1‑(2,2‑二氟苯并[D][1,3]二氧杂环戊烯‑5‑基)‑环丙烷甲酸的制备方法，其采用2‑(2‑硫代苯并[D][1,3]二氧杂环戊烯‑5‑基)乙氰为中间体，先使中间体与溴代试剂、有机碱氢氟酸盐反应生成2‑(2,2‑二氟苯并[D][1,3]二氧杂环戊烯‑5‑基)乙氰，然后由2‑(2,2‑二氟苯并[D][1,3]二氧杂环戊烯‑5‑基)乙氰依次发生成环和水解反应制得目标产物。与已有技术相比，本发明的工艺收率提高，成本较低，原料来源广泛，且没有使用有安全隐患物料，安全性好，适于工业化生产。

USPTO Abstract

本发明涉及一种1‑(2,2‑二氟苯并[D][1,3]二氧杂环戊烯‑5‑基)‑环丙烷甲酸的制备方法，其采用2‑(2‑硫代苯并[D][1,3]二氧杂环戊烯‑5‑基)乙氰为中间体，先使中间体与溴代试剂、有机碱氢氟酸盐反应生成2‑(2,2‑二氟苯并[D][1,3]二氧杂环戊烯‑5‑基)乙氰，然后由2‑(2,2‑二氟苯并[D][1,3]二氧杂环戊烯‑5‑基)乙氰依次发生成环和水解反应制得目标产物。与已有技术相比，本发明的工艺收率提高，成本较低，原料来源广泛，且没有使用有安全隐患物料，安全性好，适于工业化生产。

Drugs covered by this patent

Patent Metadata

Patent number
CN107033120B
Jurisdiction
CN
Classification
—
Expires
2020-03-17
Drug substance claim
No
Drug product claim
No
Assignee
Henan Yuchen Pharmaceutical Co ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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