CN Patent

CN106995446B — 布鲁顿酪氨酸激酶抑制剂制备方法

Assigned to Shandong New Time Pharmaceutical Co Ltd · Expires 2021-07-02 · 5y expired

What this patent protects

本发明涉及药物合成领域，具体涉及的是一种布鲁顿酪氨酸激酶抑制剂制备方法。本发明所述的新工艺是由4‑氨基‑3‑(4‑苯氧基苯基)‑1H‑吡啶并(3,4‑d)嘧啶和(S)‑叔丁基氧羰基‑3‑羟基哌啶在三苯基膦和偶氮二甲酸二异丙酯的作用下避光反应，然后在酸性条件下脱掉Boc成盐，最后用25％NaOH解盐析晶一锅制备出中间体Ⅰ，中间体Ⅰ在碱性条件下与丙烯酰氯反应生成目标产物，该制备方法生产条件简单、生产成本低、生产产率较高、环保清洁，适合工业化生产。

USPTO Abstract

本发明涉及药物合成领域，具体涉及的是一种布鲁顿酪氨酸激酶抑制剂制备方法。本发明所述的新工艺是由4‑氨基‑3‑(4‑苯氧基苯基)‑1H‑吡啶并(3,4‑d)嘧啶和(S)‑叔丁基氧羰基‑3‑羟基哌啶在三苯基膦和偶氮二甲酸二异丙酯的作用下避光反应，然后在酸性条件下脱掉Boc成盐，最后用25％NaOH解盐析晶一锅制备出中间体Ⅰ，中间体Ⅰ在碱性条件下与丙烯酰氯反应生成目标产物，该制备方法生产条件简单、生产成本低、生产产率较高、环保清洁，适合工业化生产。

Drugs covered by this patent

Patent Metadata

Patent number
CN106995446B
Jurisdiction
CN
Classification
—
Expires
2021-07-02
Drug substance claim
No
Drug product claim
No
Assignee
Shandong New Time Pharmaceutical Co Ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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