CN Patent

CN106928343A — 索玛鲁肽的制备方法

Assigned to Hybio Pharmaceutical Co Ltd · Expires 2017-07-07 · 9y expired

What this patent protects

本发明涉及多肽领域，特别涉及索玛鲁肽的制备方法。本发明采用Fmoc-Lys(Alloc)-OH保护的氨基酸为原料，选择Pd(PPh 3 ) 4 进行去保护，一方面操作过程简单，只需要简单的1～2遍脱去反应操作即可，每次10～30min，无副反应发生，操作过程安全，便于放大生产；过程中采用Boc-His(Boc)-OH.DCHA和Boc-His(Trt)-OH为原料可以最大程度降低His消旋的风险；采用特殊的片段进行偶联提高了合成效率。

USPTO Abstract

本发明涉及多肽领域，特别涉及索玛鲁肽的制备方法。本发明采用Fmoc-Lys(Alloc)-OH保护的氨基酸为原料，选择Pd(PPh 3 ) 4 进行去保护，一方面操作过程简单，只需要简单的1～2遍脱去反应操作即可，每次10～30min，无副反应发生，操作过程安全，便于放大生产；过程中采用Boc-His(Boc)-OH.DCHA和Boc-His(Trt)-OH为原料可以最大程度降低His消旋的风险；采用特殊的片段进行偶联提高了合成效率。

Drugs covered by this patent

Patent Metadata

Patent number
CN106928343A
Jurisdiction
CN
Classification
—
Expires
2017-07-07
Drug substance claim
No
Drug product claim
No
Assignee
Hybio Pharmaceutical Co Ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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