CN106854176A — 一种制备尼拉帕尼对甲苯磺酸盐一水合物的方法
Assigned to NANJING NMG-ADDS Co Ltd · Expires 2017-06-16 · 9y expired
What this patent protects
本发明公开了一种化合物2‑[4‑((3S)‑3‑哌啶基)苯基]‑2H‑吲唑‑7‑甲酰胺对甲苯磺酸盐一水合物的制备方法，通过1H‑吲唑‑7‑甲酸甲酯与(S)‑3‑(4‑卤代苯基)哌啶‑1‑甲酸叔丁酯或进行Ulman反应来制备2‑[4‑((3S)‑3‑哌啶基)苯基]‑2H‑吲唑‑7‑甲酸甲酯,后在氨气和对甲苯磺酸的条件下制得2‑[4‑((3S)‑3‑哌啶基)苯基]‑2H‑吲唑‑7‑甲酰胺对甲苯磺酸盐一水合物,本发明的目的在于避免现有方法的不足，缩短了制备路线，提供一条反应温和，易操作且手性纯度较高的2‑[4‑((3S)‑3‑哌啶基)苯基]‑2H‑吲唑‑7‑甲…
USPTO Abstract
本发明公开了一种化合物2‑[4‑((3S)‑3‑哌啶基)苯基]‑2H‑吲唑‑7‑甲酰胺对甲苯磺酸盐一水合物的制备方法，通过1H‑吲唑‑7‑甲酸甲酯与(S)‑3‑(4‑卤代苯基)哌啶‑1‑甲酸叔丁酯或进行Ulman反应来制备2‑[4‑((3S)‑3‑哌啶基)苯基]‑2H‑吲唑‑7‑甲酸甲酯,后在氨气和对甲苯磺酸的条件下制得2‑[4‑((3S)‑3‑哌啶基)苯基]‑2H‑吲唑‑7‑甲酰胺对甲苯磺酸盐一水合物,本发明的目的在于避免现有方法的不足，缩短了制备路线，提供一条反应温和，易操作且手性纯度较高的2‑[4‑((3S)‑3‑哌啶基)苯基]‑2H‑吲唑‑7‑甲酰胺对甲苯磺酸盐一水合物的制备方法。
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Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.
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