CN Patent

CN106554408A — 长效胰高血糖素样肽-1类似物二聚体及其应用

Assigned to Tianjin Institute of Pharmaceutical Research Co Ltd · Expires 2017-04-05 · 9y expired

What this patent protects

本发明提供一种胰高血糖素样肽-1类似物二聚体，所述二聚体两条胰高血糖素样肽-1类似物单体形成，所述胰高血糖素样肽-1类似物单体由通式Z 1 HX 1 EX 2 TFTSDVSSYLEGQAAKEFIX 3 WLVKX 4 RG表示，其中，Z 1 为H、乙酰基或三氟乙酰基；X1为Ala、Leu、Val、Gly、Ile；X2为Gly、Cys；X3为Ala、Cys；X4为Gly、Aib。本发明提供的胰高血糖素样肽-1类似物二聚体具有长效降血糖作用，可提高临床用药依从性，而且与内源性GLP-1(7-37)高度同源，可避免安全性风险。

USPTO Abstract

本发明提供一种胰高血糖素样肽-1类似物二聚体，所述二聚体两条胰高血糖素样肽-1类似物单体形成，所述胰高血糖素样肽-1类似物单体由通式Z 1 HX 1 EX 2 TFTSDVSSYLEGQAAKEFIX 3 WLVKX 4 RG表示，其中，Z 1 为H、乙酰基或三氟乙酰基；X1为Ala、Leu、Val、Gly、Ile；X2为Gly、Cys；X3为Ala、Cys；X4为Gly、Aib。本发明提供的胰高血糖素样肽-1类似物二聚体具有长效降血糖作用，可提高临床用药依从性，而且与内源性GLP-1(7-37)高度同源，可避免安全性风险。

Drugs covered by this patent

Patent Metadata

Patent number
CN106554408A
Jurisdiction
CN
Classification
—
Expires
2017-04-05
Drug substance claim
No
Drug product claim
No
Assignee
Tianjin Institute of Pharmaceutical Research Co Ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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