CN Patent

CN106496206A — 一种依匹哌唑新的制备方法

Assigned to Anhui Runsheng Pharmaceutical Ltd By Share Ltd · Expires 2017-03-15 · 9y expired

What this patent protects

本发明公开了一种依匹哌唑新的制备方法，本发明涉及以7‑羟基‑1H‑喹啉‑2酮(2)为起始原料，与1‑氯‑4‑溴丁烷发生取代反应，得到7‑(4‑氯丁氧基)‑1H‑喹啉‑2酮(3)；(3)在氢氧化钾的作用下，和N‑Boc哌嗪发生取代反应和脱保护基得到7‑(1‑哌嗪)丁氧基‑1H‑喹啉‑2酮二盐酸盐(4)；(4)在异丙基氯化镁作用下，发生取代反应最终得到依匹哌唑。此制备方法具有产物转化率高，产物纯净的优点，简便易行、收率高，质量好，便于工业化生产。

USPTO Abstract

本发明公开了一种依匹哌唑新的制备方法，本发明涉及以7‑羟基‑1H‑喹啉‑2酮(2)为起始原料，与1‑氯‑4‑溴丁烷发生取代反应，得到7‑(4‑氯丁氧基)‑1H‑喹啉‑2酮(3)；(3)在氢氧化钾的作用下，和N‑Boc哌嗪发生取代反应和脱保护基得到7‑(1‑哌嗪)丁氧基‑1H‑喹啉‑2酮二盐酸盐(4)；(4)在异丙基氯化镁作用下，发生取代反应最终得到依匹哌唑。此制备方法具有产物转化率高，产物纯净的优点，简便易行、收率高，质量好，便于工业化生产。

Drugs covered by this patent

Patent Metadata

Patent number
CN106496206A
Jurisdiction
CN
Classification
—
Expires
2017-03-15
Drug substance claim
No
Drug product claim
No
Assignee
Anhui Runsheng Pharmaceutical Ltd By Share Ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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