CN Patent

CN106279281B — 噁唑烷酮类抗菌素泰地唑胺磷酸酯的精制方法

Assigned to CHONGQING CHANGJIE MEDICAL CHEMICAL Co Ltd · Expires 2018-08-03 · 8y expired

What this patent protects

本发明涉及一种改进的泰地唑胺磷酸酯精制方法，其特征在于泰地唑胺磷酸酯首先在水溶液中制备泰地唑胺磷酸酯二钠盐，然后加入非极性大孔树脂吸附非极性有机杂质，然后滴加惰性有机溶剂析晶得到泰地唑胺磷酸酯二钠盐固体；将所得二钠盐固体重新溶于水中，用有机溶剂萃取除去极少量残留的有机杂质，再滴加入质子酸/惰性有机溶剂混合液析晶，抽滤，烘干得到高纯度的泰地唑胺磷酸酯，该精制方法工艺简便、收率高、经济环保、适合工业化生产。

USPTO Abstract

本发明涉及一种改进的泰地唑胺磷酸酯精制方法，其特征在于泰地唑胺磷酸酯首先在水溶液中制备泰地唑胺磷酸酯二钠盐，然后加入非极性大孔树脂吸附非极性有机杂质，然后滴加惰性有机溶剂析晶得到泰地唑胺磷酸酯二钠盐固体；将所得二钠盐固体重新溶于水中，用有机溶剂萃取除去极少量残留的有机杂质，再滴加入质子酸/惰性有机溶剂混合液析晶，抽滤，烘干得到高纯度的泰地唑胺磷酸酯，该精制方法工艺简便、收率高、经济环保、适合工业化生产。

Drugs covered by this patent

Patent Metadata

Patent number
CN106279281B
Jurisdiction
CN
Classification
—
Expires
2018-08-03
Drug substance claim
No
Drug product claim
No
Assignee
CHONGQING CHANGJIE MEDICAL CHEMICAL Co Ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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