CN Patent

CN105985317B — 一种色瑞替尼的制备方法及其中间体

Assigned to Southeast Pharmaceuticals Co ltd · Expires 2018-09-18 · 8y expired

What this patent protects

本发明涉及药物化学领域，具体涉及一种色瑞替尼的制备方法及其中间体，该方法以2,4‑二氯‑5‑硝基嘧啶为原料，经两步缩合反应得式Ⅴ化合物，式Ⅴ化合物后经还原、氯代和脱除保护基R得色瑞替尼。该方法显著提高该步反应收率，并且反应条件温和、产物无须柱层析纯化，适合工业化生产并且避免重金属残留。

USPTO Abstract

本发明涉及药物化学领域，具体涉及一种色瑞替尼的制备方法及其中间体，该方法以2,4‑二氯‑5‑硝基嘧啶为原料，经两步缩合反应得式Ⅴ化合物，式Ⅴ化合物后经还原、氯代和脱除保护基R得色瑞替尼。该方法显著提高该步反应收率，并且反应条件温和、产物无须柱层析纯化，适合工业化生产并且避免重金属残留。

Drugs covered by this patent

Patent Metadata

Patent number
CN105985317B
Jurisdiction
CN
Classification
—
Expires
2018-09-18
Drug substance claim
No
Drug product claim
No
Assignee
Southeast Pharmaceuticals Co ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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