CN Patent

CN105968040B — 一种雷迪帕韦中间体的制备方法

Assigned to Astatech (chengdu) Biological Pharmaceutical Ltd By Share Ltd · Expires 2019-02-05 · 7y expired

What this patent protects

本发明公开了一种式(Ⅲ)所示雷迪帕韦中间体的制备方法。该方法以(1R,3S,4S)‑N‑叔丁氧羰基‑2‑氮杂双环[2.2.1]庚烷‑3‑羧酸和邻苯二胺为原料，采用混酐的方法合成(1R,3S,4S)‑3‑(6‑溴‑1H‑苯并咪唑‑2‑基)‑2‑氮杂双环[2.2.1]庚烷‑2‑羧酸叔丁酯。整条路线生产成本低，收率高；形成的单酰胺易于纯化，减少了杂质的产品和残留；且原料邻苯二胺便宜易得，不易被氧化变色，可以大量储存，利于工业化生产。

USPTO Abstract

本发明公开了一种式(Ⅲ)所示雷迪帕韦中间体的制备方法。该方法以(1R,3S,4S)‑N‑叔丁氧羰基‑2‑氮杂双环[2.2.1]庚烷‑3‑羧酸和邻苯二胺为原料，采用混酐的方法合成(1R,3S,4S)‑3‑(6‑溴‑1H‑苯并咪唑‑2‑基)‑2‑氮杂双环[2.2.1]庚烷‑2‑羧酸叔丁酯。整条路线生产成本低，收率高；形成的单酰胺易于纯化，减少了杂质的产品和残留；且原料邻苯二胺便宜易得，不易被氧化变色，可以大量储存，利于工业化生产。

Drugs covered by this patent

Patent Metadata

Patent number: CN105968040B
Jurisdiction: CN
Classification: —
Expires: 2019-02-05
Drug substance claim: No
Drug product claim: No
Assignee: Astatech (chengdu) Biological Pharmaceutical Ltd By Share Ltd
Source: FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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