CN Patent

CN105899663B — 用于基因表达控制的人工模拟miRNA及其用途

Assigned to Tokyo Medical University · Expires 2019-07-26 · 7y expired

What this patent protects

本发明提供一种利用了miRNA的新的人工模拟miRNA。将单链核酸作为人工模拟miRNA，所述单链核酸的X区域和Y区域连结，所述X区域为成熟miRNA的引导链序列或其部分序列，由相对于所述Y区域的连结侧区域(X B )及非连结侧区域(X F )构成，所述连结侧区域(X B )为在该区域内不进行分子内退火的序列，所述Y区域为与所述X区域的所述非连结侧区域(X F )进行分子内退火的序列。根据该人工模拟miRNA，可以抑制所述目标基因的表达。

USPTO Abstract

本发明提供一种利用了miRNA的新的人工模拟miRNA。将单链核酸作为人工模拟miRNA，所述单链核酸的X区域和Y区域连结，所述X区域为成熟miRNA的引导链序列或其部分序列，由相对于所述Y区域的连结侧区域(X B )及非连结侧区域(X F )构成，所述连结侧区域(X B )为在该区域内不进行分子内退火的序列，所述Y区域为与所述X区域的所述非连结侧区域(X F )进行分子内退火的序列。根据该人工模拟miRNA，可以抑制所述目标基因的表达。

Drugs covered by this patent

Patent Metadata

Patent number
CN105899663B
Jurisdiction
CN
Classification
—
Expires
2019-07-26
Drug substance claim
No
Drug product claim
No
Assignee
Tokyo Medical University
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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