CN Patent

CN105669594A — 抗抑郁症药1-[2-(2,4-二甲基苯基硫基)苯基]哌嗪的制备方法

Assigned to Kamp Pharmaceuticals Co Ltd · Expires 2016-06-15 · 10y expired

What this patent protects

本发明涉及抗抑郁症药1-[2-(2,4-二甲基苯基硫基)苯基]哌嗪(VI)的制备方法，包括：以2,4-二甲基苯硫酚(I)为起始原料，与2-卤代硝基苯(II)缩合生成2-(2，4-二甲基苯基硫烷基)硝基苯(III)，2-(2，4-二甲基苯基硫烷基)硝基苯(III)经还原得到2-(2，4-二甲基苯基硫烷基)苯胺(IV)，再与双(2-氯乙基)胺盐酸盐(V)合环生成1-[2-(2,4-二甲基苯基硫基)苯基]哌嗪(VI)。本发明的制备方法原料低廉易得，工艺简洁，经济环保、适合工业化生产。

USPTO Abstract

本发明涉及抗抑郁症药1-[2-(2,4-二甲基苯基硫基)苯基]哌嗪(VI)的制备方法，包括：以2,4-二甲基苯硫酚(I)为起始原料，与2-卤代硝基苯(II)缩合生成2-(2，4-二甲基苯基硫烷基)硝基苯(III)，2-(2，4-二甲基苯基硫烷基)硝基苯(III)经还原得到2-(2，4-二甲基苯基硫烷基)苯胺(IV)，再与双(2-氯乙基)胺盐酸盐(V)合环生成1-[2-(2,4-二甲基苯基硫基)苯基]哌嗪(VI)。本发明的制备方法原料低廉易得，工艺简洁，经济环保、适合工业化生产。

Drugs covered by this patent

vortioxetine-hydrobromide (VORTIOXETINE HYDROBROMIDE)

Patent Metadata

Patent number: CN105669594A
Jurisdiction: CN
Classification: —
Expires: 2016-06-15
Drug substance claim: No
Drug product claim: No
Assignee: Kamp Pharmaceuticals Co Ltd
Source: FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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