CN Patent

CN105566429B — 一种奥贝胆酸1型的制备方法

Assigned to Chang'ao Pharmaceutical Technology Holdings Ltd · Expires 2020-12-01 · 5y expired

What this patent protects

本发明公开了一种奥贝胆酸1型的制备方法，制备过程如下：首先将3α‑羟基‑6α‑乙基‑7‑酮‑5β‑胆烷‑24‑酸或3α‑羟基‑6α‑乙基‑7‑酮‑5β‑胆烷‑24‑酸酯、碱和溶剂的混合物升温至75~105℃，加入还原剂进行反应，TLC跟踪原料反应完全，冷却反应液至30~50℃，加入有机溶剂和水，盐酸调节溶液pH值至3‑5，分液，有机相减压蒸干得无色至浅黄色油状残余物；然后将所得残余物加入水和碱，升温溶解，得溶液；最后将所得溶液，缓慢滴加稀盐酸溶液调节pH值至3‑4，降温，搅拌结晶，过滤，真空干燥得奥贝胆酸1型。

USPTO Abstract

本发明公开了一种奥贝胆酸1型的制备方法，制备过程如下：首先将3α‑羟基‑6α‑乙基‑7‑酮‑5β‑胆烷‑24‑酸或3α‑羟基‑6α‑乙基‑7‑酮‑5β‑胆烷‑24‑酸酯、碱和溶剂的混合物升温至75~105℃，加入还原剂进行反应，TLC跟踪原料反应完全，冷却反应液至30~50℃，加入有机溶剂和水，盐酸调节溶液pH值至3‑5，分液，有机相减压蒸干得无色至浅黄色油状残余物；然后将所得残余物加入水和碱，升温溶解，得溶液；最后将所得溶液，缓慢滴加稀盐酸溶液调节pH值至3‑4，降温，搅拌结晶，过滤，真空干燥得奥贝胆酸1型。

Drugs covered by this patent

Patent Metadata

Patent number
CN105566429B
Jurisdiction
CN
Classification
—
Expires
2020-12-01
Drug substance claim
No
Drug product claim
No
Assignee
Chang'ao Pharmaceutical Technology Holdings Ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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