CN Patent

CN105541953B — 一种高纯度奥贝胆酸的重结晶纯化方法

Assigned to Sichuan Xin Gong biological science and Technology Group Co., Ltd. · Expires 2017-11-21 · 8y expired

What this patent protects

本发明公开了一种高纯度奥贝胆酸的重结晶纯化方法，它是将奥贝胆酸与有机胺成盐后在有机溶剂中重结晶而获得高纯度奥贝胆酸的方法，具体操作是先将奥贝胆酸粗品在有机溶剂中与有机胺反应获得奥贝胆酸有机胺盐；再将所述奥贝胆酸有机胺盐进行酸调，使其以奥贝胆酸形式重结晶。本发明所述的纯化方法能够获得高纯度(纯度＞98.5％、单杂＜0.1％)的奥贝胆酸，且方法无需采用柱层析等不能大量生产高纯度奥贝胆酸的步骤，因此本发明所述的纯化方法更能适应工业化生产。

USPTO Abstract

本发明公开了一种高纯度奥贝胆酸的重结晶纯化方法，它是将奥贝胆酸与有机胺成盐后在有机溶剂中重结晶而获得高纯度奥贝胆酸的方法，具体操作是先将奥贝胆酸粗品在有机溶剂中与有机胺反应获得奥贝胆酸有机胺盐；再将所述奥贝胆酸有机胺盐进行酸调，使其以奥贝胆酸形式重结晶。本发明所述的纯化方法能够获得高纯度(纯度＞98.5％、单杂＜0.1％)的奥贝胆酸，且方法无需采用柱层析等不能大量生产高纯度奥贝胆酸的步骤，因此本发明所述的纯化方法更能适应工业化生产。

Drugs covered by this patent

Patent Metadata

Patent number
CN105541953B
Jurisdiction
CN
Classification
—
Expires
2017-11-21
Drug substance claim
No
Drug product claim
No
Assignee
Sichuan Xin Gong biological science and Technology Group Co., Ltd.
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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