CN Patent

CN105541798B — 具有抗肿瘤活性的喹啉类多靶点激酶抑制剂及其制备方法

Assigned to Second Military Medical University SMMU · Expires 2018-01-23 · 8y expired

What this patent protects

本发明涉及具有抗肿瘤活性的喹啉类多靶点激酶抑制剂及其制备方法，所述化合物的结构通式如式(I)所示。通过体外细胞实验证实本发明的化合物对五种常见的肿瘤细胞株人甲状腺癌SW579、人肝癌HepG2、人肺腺癌A549、人肠癌HCT116和人胃癌MKN45具有很强的体外抑制活性，多数目标化合物的抑瘤活性优于或相当于阳性对照药Cabozantinib，且通过体外细胞实验证实其对两种激酶KDR和MET显示出较强的抑制活性，提示本发明的化合物在制备新的抗肿瘤药物方面具有广阔的应用前景。

USPTO Abstract

本发明涉及具有抗肿瘤活性的喹啉类多靶点激酶抑制剂及其制备方法，所述化合物的结构通式如式(I)所示。通过体外细胞实验证实本发明的化合物对五种常见的肿瘤细胞株人甲状腺癌SW579、人肝癌HepG2、人肺腺癌A549、人肠癌HCT116和人胃癌MKN45具有很强的体外抑制活性，多数目标化合物的抑瘤活性优于或相当于阳性对照药Cabozantinib，且通过体外细胞实验证实其对两种激酶KDR和MET显示出较强的抑制活性，提示本发明的化合物在制备新的抗肿瘤药物方面具有广阔的应用前景。

Drugs covered by this patent

Patent Metadata

Patent number
CN105541798B
Jurisdiction
CN
Classification
—
Expires
2018-01-23
Drug substance claim
No
Drug product claim
No
Assignee
Second Military Medical University SMMU
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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