CN Patent

CN105504012A — 一种多肽的制备方法

Assigned to Hybio Pharmaceutical Co Ltd · Expires 2016-04-20 · 10y expired

What this patent protects

本发明涉及多肽领域，特别涉及一种多肽的制备方法。该制备方法包括如下步骤：取Arg与树脂偶联，制得Arg-树脂；取Arg-树脂，逐个偶联Ala、Arg、Arg、Arg、Ala、Cys(X)后，将氮端氨基乙酰化，得到第一肽树脂；脱除第一肽树脂中Cys(X)的侧链保护基X，再与Y-Cys偶联，获得第二肽树脂，裂解，即得。该方法为纯固相工艺，操作简便，假稀释效应避免了液相反应中存在的多肽链间二硫键错配的反应(不会产生肽链间反应)。提高了多肽Velcalcetide的收率和纯度，减少了副反应的发生。

USPTO Abstract

本发明涉及多肽领域，特别涉及一种多肽的制备方法。该制备方法包括如下步骤：取Arg与树脂偶联，制得Arg-树脂；取Arg-树脂，逐个偶联Ala、Arg、Arg、Arg、Ala、Cys(X)后，将氮端氨基乙酰化，得到第一肽树脂；脱除第一肽树脂中Cys(X)的侧链保护基X，再与Y-Cys偶联，获得第二肽树脂，裂解，即得。该方法为纯固相工艺，操作简便，假稀释效应避免了液相反应中存在的多肽链间二硫键错配的反应(不会产生肽链间反应)。提高了多肽Velcalcetide的收率和纯度，减少了副反应的发生。

Drugs covered by this patent

Patent Metadata

Patent number
CN105504012A
Jurisdiction
CN
Classification
—
Expires
2016-04-20
Drug substance claim
No
Drug product claim
No
Assignee
Hybio Pharmaceutical Co Ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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