CN Patent

CN105503739B — 一种奥拉帕尼的制备方法

Assigned to Hefei Kai Yang Biological Technology Co. Ltd. · Expires 2018-09-11 · 8y expired

What this patent protects

本发明公开了一种高纯度奥拉帕尼的制备方法，是以2‑氟‑5‑[(4‑氧代‑3,4‑二氢二氮杂萘‑1‑基)甲基]苯甲酸为起始原料，经活化、胺解结晶后得到高纯度奥拉帕尼，其中活化是向含有2‑氟‑5‑[(4‑氧代‑3,4‑二氢二氮杂萘‑1‑基)甲基]苯甲酸的溶液中加入羰基二咪唑活化剂，制得活性酰胺中间体；活性酰胺中间体不经分离纯化，直接与1‑环丙甲酰基哌嗪胺解结晶，制得奥拉帕尼。本发明方法制备的奥拉帕尼的纯度大于99.8％，工艺简捷，收率高，成本低，更适合工业化生产。

USPTO Abstract

本发明公开了一种高纯度奥拉帕尼的制备方法，是以2‑氟‑5‑[(4‑氧代‑3,4‑二氢二氮杂萘‑1‑基)甲基]苯甲酸为起始原料，经活化、胺解结晶后得到高纯度奥拉帕尼，其中活化是向含有2‑氟‑5‑[(4‑氧代‑3,4‑二氢二氮杂萘‑1‑基)甲基]苯甲酸的溶液中加入羰基二咪唑活化剂，制得活性酰胺中间体；活性酰胺中间体不经分离纯化，直接与1‑环丙甲酰基哌嗪胺解结晶，制得奥拉帕尼。本发明方法制备的奥拉帕尼的纯度大于99.8％，工艺简捷，收率高，成本低，更适合工业化生产。

Drugs covered by this patent

Patent Metadata

Patent number
CN105503739B
Jurisdiction
CN
Classification
—
Expires
2018-09-11
Drug substance claim
No
Drug product claim
No
Assignee
Hefei Kai Yang Biological Technology Co. Ltd.
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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