CN Patent

CN105461715B — 一种利奥西呱中间体的合成方法

Assigned to Lanzhou Bosheng Kangyuan Pharmaceutical Co ltd · Expires 2017-03-29 · 9y expired

What this patent protects

本发明公开了一种利奥西呱中间体的合成方法，首先以1‑（2‑氟苄基）‑1H‑吡唑并[3,4‑b]吡啶‑3‑甲脒盐酸盐为起始原料，通过催化剂常压催化加氢制备利奥西呱关键中间体2‑[1‑(2‑氟苄基)‑1H‑吡唑并[3,4‑b]吡啶‑3‑基]‑4,5,6‑嘧啶三胺。本发明合成工艺反应条件温和，避免使用高压反应釜，降低工艺对设备的要求，最终产品纯度大于99.0%，适于工业化生产。

USPTO Abstract

本发明公开了一种利奥西呱中间体的合成方法，首先以1‑（2‑氟苄基）‑1H‑吡唑并[3,4‑b]吡啶‑3‑甲脒盐酸盐为起始原料，通过催化剂常压催化加氢制备利奥西呱关键中间体2‑[1‑(2‑氟苄基)‑1H‑吡唑并[3,4‑b]吡啶‑3‑基]‑4,5,6‑嘧啶三胺。本发明合成工艺反应条件温和，避免使用高压反应釜，降低工艺对设备的要求，最终产品纯度大于99.0%，适于工业化生产。

Drugs covered by this patent

Patent Metadata

Patent number
CN105461715B
Jurisdiction
CN
Classification
—
Expires
2017-03-29
Drug substance claim
No
Drug product claim
No
Assignee
Lanzhou Bosheng Kangyuan Pharmaceutical Co ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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