CN Patent

CN105330706B — 卡格列净中间体的制备方法

Assigned to Changzhou Hengbang Pharmaceutical Co ltd · Expires 2019-04-16 · 7y expired

What this patent protects

本发明提供一种卡格列净中间体的制备方法，所述方法包括以下步骤：将2,3,4,6‑四‑O‑(三甲基硅)‑D‑葡萄糖酸‑δ‑内酯与2‑(4‑氟苯基)‑5‑[(5‑碘‑2‑甲基苯基)甲基]噻吩加入有机溶剂A中,在低温条件下加入碱性试剂，反应完全后加入酸性醇溶液脱保护并酸处理，加入碱性溶液调pH值至7～8，静置分出有机层，水层用有机溶剂B提取，合并有机层，洗涤、干燥、过滤、浓缩得油状物，油状物析晶、过滤，得到卡格列净中间体。本发明反应操作简单、适合工业化生产，且产率高，纯度好。

USPTO Abstract

本发明提供一种卡格列净中间体的制备方法，所述方法包括以下步骤：将2,3,4,6‑四‑O‑(三甲基硅)‑D‑葡萄糖酸‑δ‑内酯与2‑(4‑氟苯基)‑5‑[(5‑碘‑2‑甲基苯基)甲基]噻吩加入有机溶剂A中,在低温条件下加入碱性试剂，反应完全后加入酸性醇溶液脱保护并酸处理，加入碱性溶液调pH值至7～8，静置分出有机层，水层用有机溶剂B提取，合并有机层，洗涤、干燥、过滤、浓缩得油状物，油状物析晶、过滤，得到卡格列净中间体。本发明反应操作简单、适合工业化生产，且产率高，纯度好。

Drugs covered by this patent

Patent Metadata

Patent number
CN105330706B
Jurisdiction
CN
Classification
—
Expires
2019-04-16
Drug substance claim
No
Drug product claim
No
Assignee
Changzhou Hengbang Pharmaceutical Co ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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