CN Patent

CN105330616B — 卡利拉嗪的制备方法

Assigned to Zhongkongirit Yantai Technology Development Co ltd · Expires 2017-09-26 · 9y expired

What this patent protects

本发明揭示了一种卡利拉嗪(Cariprazine，RGH 188)的制备方法，其制备步骤包括：4‑(2‑羟基乙基)环己酮与1‑(2,3‑二氯苯基)哌嗪经缩合反应制得4‑[2‑[4‑(2,3‑二氯苯基)哌嗪)‑1‑基]乙基]环己酮，所得中间体经还原氨解反应制得trans‑4‑[2‑[4‑(2,3‑二氯苯基)哌嗪)‑1‑基]乙基]环己胺，该中间体与N,N‑二甲基甲氨基甲酰氯发生酰化反应制得卡利拉嗪。该制备方法原料易得，工艺简洁，经济环保，适合工业化生产。

USPTO Abstract

本发明揭示了一种卡利拉嗪(Cariprazine，RGH 188)的制备方法，其制备步骤包括：4‑(2‑羟基乙基)环己酮与1‑(2,3‑二氯苯基)哌嗪经缩合反应制得4‑[2‑[4‑(2,3‑二氯苯基)哌嗪)‑1‑基]乙基]环己酮，所得中间体经还原氨解反应制得trans‑4‑[2‑[4‑(2,3‑二氯苯基)哌嗪)‑1‑基]乙基]环己胺，该中间体与N,N‑二甲基甲氨基甲酰氯发生酰化反应制得卡利拉嗪。该制备方法原料易得，工艺简洁，经济环保，适合工业化生产。

Drugs covered by this patent

Patent Metadata

Patent number
CN105330616B
Jurisdiction
CN
Classification
—
Expires
2017-09-26
Drug substance claim
No
Drug product claim
No
Assignee
Zhongkongirit Yantai Technology Development Co ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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