CN105218329B — 一种列净类似物中间体及其制备方法
Assigned to Shanghai Xin Ping Medical Sci-Tech Development Co Ltd · Expires 2017-05-03 · 9y expired
What this patent protects
本发明提供了一种列净类似物中间体，其结构式如下所示： 还提供了上述的列净类似物中间体的制备方法，先制备6‑甲基‑2‑氧代环己基‑3‑烯甲酸甲酯；再制备3‑溴‑6‑甲基水杨酸甲酯；再制备2‑甲氧基‑3‑溴‑6甲基苯甲酸甲酯；再制备2‑甲氧基‑3‑溴‑6‑甲基苯甲酸；再制备3‑溴‑2‑甲氧基‑6‑甲基‑N，O‑二甲基羟苯甲酰胺；再制备(3‑溴‑2‑甲氧基‑6‑甲基苯基)(4’‑取代基苯基)甲酮；再制备(3‑溴‑2‑甲氧基‑6‑甲基苯基)(4’‑取代基苯基)甲烷。本发明避免了邻对位异构体的形成，同时收率也高于90％。
USPTO Abstract
本发明提供了一种列净类似物中间体，其结构式如下所示： 还提供了上述的列净类似物中间体的制备方法，先制备6‑甲基‑2‑氧代环己基‑3‑烯甲酸甲酯；再制备3‑溴‑6‑甲基水杨酸甲酯；再制备2‑甲氧基‑3‑溴‑6甲基苯甲酸甲酯；再制备2‑甲氧基‑3‑溴‑6‑甲基苯甲酸；再制备3‑溴‑2‑甲氧基‑6‑甲基‑N，O‑二甲基羟苯甲酰胺；再制备(3‑溴‑2‑甲氧基‑6‑甲基苯基)(4’‑取代基苯基)甲酮；再制备(3‑溴‑2‑甲氧基‑6‑甲基苯基)(4’‑取代基苯基)甲烷。本发明避免了邻对位异构体的形成，同时收率也高于90％。
Drugs covered by this patent
- Farxiga (DAPAGLIFLOZIN) · AstraZeneca
Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.
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