CN Patent

CN105175370A — 一种2-氟-5-[(3-氧代-1(3h)-异苯并呋喃亚基)甲基]苯腈的合成方法

Assigned to ANHUI WANBANG MEDICAL TECHNOLOGY Co Ltd · Expires 2015-12-23 · 10y expired

What this patent protects

一种奥拉帕尼中间体2-氟-5-[(3-氧代-1(3H)-异苯并呋喃亚基)甲基]苯腈的新合成方法，以3-亚甲基异苯并呋喃-1(3H)-酮与2-氟-5-溴苯腈为反应原料，在碱性条件与金属钯类化合物的催化下，经偶联反应得到2-氟-5-[(3-氧代-1(3H)-异苯并呋喃亚基)甲基]苯腈，反应收率70%以上。与原工艺路线相比，避免了甲醇钠、甲磺酸等强碱强酸对设备腐蚀性较强类物的使用，并且缩短了反应步骤，使操作更加简便，减少了对环境的冲击力大，降低了成本。

USPTO Abstract

一种奥拉帕尼中间体2-氟-5-[(3-氧代-1(3H)-异苯并呋喃亚基)甲基]苯腈的新合成方法，以3-亚甲基异苯并呋喃-1(3H)-酮与2-氟-5-溴苯腈为反应原料，在碱性条件与金属钯类化合物的催化下，经偶联反应得到2-氟-5-[(3-氧代-1(3H)-异苯并呋喃亚基)甲基]苯腈，反应收率70%以上。与原工艺路线相比，避免了甲醇钠、甲磺酸等强碱强酸对设备腐蚀性较强类物的使用，并且缩短了反应步骤，使操作更加简便，减少了对环境的冲击力大，降低了成本。

Drugs covered by this patent

Patent Metadata

Patent number
CN105175370A
Jurisdiction
CN
Classification
—
Expires
2015-12-23
Drug substance claim
No
Drug product claim
No
Assignee
ANHUI WANBANG MEDICAL TECHNOLOGY Co Ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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