CN105017282B — 帕克替尼的制备方法
Assigned to SCI GENERAL MATERIAL & CHEMICAL Inc. · Expires 2017-11-07 · 9y expired
What this patent protects
本发明揭示了一种制备帕克替尼(Pacritinib，I)的制备方法。通过式II化合物1‑[3‑(4‑溴‑2‑丁烯)甲醇基苯基]‑3‑二甲氨基‑2‑丙烯‑1‑酮和式III化合物2‑[2‑(1‑吡咯烷基)乙氧基)]‑5‑胍基苯基甲醇在碱促进剂作用下进行环合反应制得帕克替尼(I)。该制备方法具有原料易得、工艺简洁、经济环保且适合工业化生产等特点。本发明还揭示了两种可用于制备帕克替尼的中间体及其制备方法。
USPTO Abstract
本发明揭示了一种制备帕克替尼(Pacritinib，I)的制备方法。通过式II化合物1‑[3‑(4‑溴‑2‑丁烯)甲醇基苯基]‑3‑二甲氨基‑2‑丙烯‑1‑酮和式III化合物2‑[2‑(1‑吡咯烷基)乙氧基)]‑5‑胍基苯基甲醇在碱促进剂作用下进行环合反应制得帕克替尼(I)。该制备方法具有原料易得、工艺简洁、经济环保且适合工业化生产等特点。本发明还揭示了两种可用于制备帕克替尼的中间体及其制备方法。
Drugs covered by this patent
Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.
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