CN Patent

CN104710413B — 二马来酸阿法替尼的制备方法

Assigned to Jiangsu Hansoh Pharmaceutical Group Co Ltd · Expires 2019-05-03 · 7y expired

What this patent protects

本发明涉及二马来酸阿法替尼的制备方法。具体而言，本发明涉及抗肿瘤药物阿法替尼二马来酸盐的制备方法，其包括如下步骤：6‑氨基‑7‑氟‑3,4‑二氢喹唑啉‑4‑酮和(S)‑3‑羟基四氢呋喃发生取代反应后，经过还原、酰胺化、缩合、成盐制得如式（I）所示的二马来酸阿法替尼。该制备方法工艺简洁、经济和环保，适合工业化放大的要求。

USPTO Abstract

本发明涉及二马来酸阿法替尼的制备方法。具体而言，本发明涉及抗肿瘤药物阿法替尼二马来酸盐的制备方法，其包括如下步骤：6‑氨基‑7‑氟‑3,4‑二氢喹唑啉‑4‑酮和(S)‑3‑羟基四氢呋喃发生取代反应后，经过还原、酰胺化、缩合、成盐制得如式（I）所示的二马来酸阿法替尼。该制备方法工艺简洁、经济和环保，适合工业化放大的要求。

Drugs covered by this patent

Patent Metadata

Patent number
CN104710413B
Jurisdiction
CN
Classification
—
Expires
2019-05-03
Drug substance claim
No
Drug product claim
No
Assignee
Jiangsu Hansoh Pharmaceutical Group Co Ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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